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sma4dBioGRID Interaction 297491 Between SEMA4D And PTPRC. sema domain, immunoglobulin domain (), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4DEvans and colleagues describe a novel immunomodulatory function of semaphorin 4D (SEMA4D) and show that blocking SEMA4D enhances immune infiltration into tumor