wb403WB403 is a TGR5 activator. WB403 snificantly decreases fasting blood glucose, postprandial blood glucose and HbA1c, improves glucose tolerance in type 2 diabetic mice. WB403WB403 preserved the mass of pancreatic β-cells and normal distribution of α and β-cells. (A) H&E staining of pancreas from dbdb mice, and statistical result. Islets were sized by